For online colleges that offer online degrees/programs, University of Southern California provides the most number of online programs (75 online programs) and Columbia University in the City of New York has the second most online major programs (18 online programs) based on academic year 2019-2020 college enrollment data.
Below table ranks and compares the Online Colleges with Most Major Programs having the largest number of online programs. For the ranking, we include colleges with more than 50% online students who enrolled online exclusively.

Online Colleges with Most Major Programs Comparison Table

RankCollege NameIn-State Tuition & FeesOut-of-State Tuition & FeesStudent Population (Total)Online Student PopulationNumber of ProgramsNumber of Online ProgramsStudents to Faculty Ratio
1University of Southern California
Los Angeles, CA
$54,259$60,27546,28737,923600759 to 1
2Columbia University in the City of New York
New York, NY
$51,640$60,53230,13525,843465186 to 1
3University of Maryland-College Park
College Park, MD
$10,779$36,89140,70923,231429317 to 1
4Michigan State University
East Lansing, MI
$15,555$40,38449,69540,9743831816 to 1
5University of Illinois at Urbana-Champaign
Champaign, IL
$17,213$36,72052,67930,6283743320 to 1
6Wayne State University
Detroit, MI
$14,629$31,49926,24118,8833743215 to 1
7University of Connecticut
Storrs, CT
$17,834$40,50227,21514,2303683016 to 1
8Harvard University
Cambridge, MA
$48,949$53,96830,39127,933368-5 to 1
9Johns Hopkins University
Baltimore, MD
$52,170$54,16028,89019,989355706 to 1
10University of Pennsylvania
Philadelphia, PA
$53,534$60,04226,55217,08734846 to 1
Average$12,834$17,0277,612,4536,226,864641816 to 1